항암치료가 암을 빠르게 전이시킨다[ 하버드의대교수 연구발표 ]내츄럴뉴스

항암치료가 암을 빠르게 전이시켜[하버드의대교수 연구발표 ]내츄럴뉴스   항암치료가 암을 빠르고 크게 자라게 만든다[케모테라피 항암치료부작용]  깜짝 놀랄 뉴스 : 암치료제가 종양을 더 공격적이고 심각하게 만든다 Breaking news: cancer drugs make tumors more aggressive and deadly   By S. L. Baker   Jan 19, 2012 - 5:38:25 PM 이 이야기는 자연건강보호주의의 입장을 견지한 의료인들이 의학계 주류인사와 제약사들이 사용하는 암치료 방법의 문제점을 개선하려는 노력의 결과들이다. 요점은 주류 의학계 암치료제인 케모테라피 (화학요법)와 방사선 치료를 암환자에게 적용하면 엉뚱하게도 이 치료법이 환자의 몸을 약화시키고 손상을 준다는 것이다. 그것도 암이 급하게 발병하는 현상을 포함해 여러모로 말이다. 아래 기사는 과학진이 기존의 암치료법의 문제가 어디서 발생했는지를 밝혀낸 내용이다. 문제의 시발점은 화학요법은 종양을 일시적으로 죽이기도 하고 위축시킬 수있으나, 정작 그 방법은 악영향을 끼쳐서 장기적으로 더 심각한 상태로 발전시킨다는 것이다. 내춰럴뉴스는 이렇게 보고한다. http://www.naturalnews.com/029042_cancer_cells_chemotherapy.html 알라바마 대학 버밍검 캠퍼스의 통합 암센터 과학자들은 화학요법이 가해진 후에 암세포가 죽은 것이 남아있게 되며 그것이 몸의 다른 장기로 번지는 전이현상 (metastasis)이 발생한다는 것이다. 그것은 아직 제대로 규명되지않은 주피세포 (페리사이트)의 존재유무로 발견되는데 이는 악성종양 자체의 마이크로 수준의 조건에서는 암의 진행을 멈추게 된다. 그런데 이 주피세포가 파괴된 경우에는 어떤 항암치료를 가했을 때 뜻하지 않게 암세포를 더 공격적으로 만들기에 다른 곳에 번지는 것이고 종국에는 죽음에 이르게 된다는 것이다. 암세포 저널의 1월17일자 연구보고서는 결론으로 보고하기를 신생혈관생성 억제요법anti-angiogenic therapies  이 인체의 면역력을 죽일 수있는데 그 이유는 요법이 암세포의 진전을 막아주는 주피세포를 파괴하기에 그렇게 된다는 것이다. 주피 세포는 암세포에 대항하는 중요한 역할을 하면서 혈관을 보호하고 생장을 돕는 것이다. 이스라엘 디콘의료센터의 매트릭스 생물학과장이며 하바드의대 교수인 라그 칼루리 박사는 새로운 연구에서 주피세포를 목표물로 해서 양성종양의 생장을 막을 수있는지 여부를 조사했다. 이는 신생혈관 생성억제요법으로 암치료제를 적용한 것과 동일한 방식이었다. 이 방법은 실험대상 동물에 대하여 적용했을 때 대략 30퍼센트의 악성 종양의 사이즈를 줄여준 것이었다. 이는 25여일이 걸렸다. 그러나 이 결과에는 심각한 문제가 따라왔다. 그 문제란 주류의학계의 상식에 반하여 이들 과학진은 2차적 폐 양성종양세포가 실험용 쥐에 대하여 3배나 증가하는 것이었기 때문이다. 이것은 양성종양이 전이됬다는 사실을 보여준 것이다. 암치료제는 어떻게 암세포를 전이시키는가 (이하 번역생략)

Breaking news: cancer drugs make tumors more aggressive and deadly

Thursday, January 19, 2012 by: S. L. Baker, features writer

(NaturalNews) When natural health advocates warn against mainstream medicine's arsenal of weapons used to fight cancer, including chemotherapy and radiation, their concerns often revolve around how these therapies can weaken and damage a person's body in numerous ways. But scientists are finding other reasons to question some of these therapies. It turns out that while chemotherapies may kill or shrink tumors in the short term, they may actually be causing malignancies to grow more deadly in the long term.

For example, NaturalNews previously reported (http://www.naturalnews.com/029042_cancer_cells_chemotherapy.html) that scientists at the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center and UAB Department of Chemistry are currently investigating the very real possibility that dead cancer cells left over after chemotherapy spark cancer to spread to other parts of the body (metastasis). And now comes news that a little-explored specific cell type, the pericyte, found in what is called the microenvironment of a cancerous tumor actually may halt cancer progression and metastasis. And by destroying these cells, some anti-cancer therapies may inadvertently be making cancer more aggressive as well as likely to spread and kill.

A study just published in the January 17 issue of the journal Cancer Cell concludes that anti-angiogenic therapies (which shrink cancer by cutting off tumors' blood supply) may be killing the body's natural defense against cancer by destroying pericyte cells that likely serve as important gatekeepers against cancer progression and metastasis. Pericytes cover blood vessels and support their growth.
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For the new research, Raghu Kalluri, MD, PhD, Chief of the Division of Matrix Biology at Beth Israel Deaconess Medical Center (BIDMC) and Professor of Medicine at Harvard Medical School (HMS), investigated whether targeting pericytes could inhibit tumor growth in the same way that other antiangiogenic cancer drugs do.

Dr. Kalluri and his research team worked with mice genetically engineered to support drug-induced depletion of pericytes in growing tumors. Next, they removed pericytes in implanted mouse breast cancer tumors, decreasing pericyte numbers by 60 percent.

Compared with control animals, there was a 30 percent decrease in the size of cancerous tumors over 25 days. But there was a serious catch to these results. Contrary to conventional mainsteam medical wisdom, the scientists discovered the number of secondary lung tumors in the engineered mice had increased threefold compared to the control mice, indicating that the tumors had metastasized.

How cancer drugs can spread cancer cells

"If you just looked at tumor growth, the results were good," Dr. Kalluri said in a press statement. "But when you looked at the whole picture, inhibiting tumor vessels was not controlling cancer progression. The cancer was, in fact, spreading. This suggested to us that without supportive pericytes, the vasculature inside the tumor was becoming weak and leaky -- even more so than it already is inside most tumors-- and this was reducing the flow of oxygen to the tumor."

That change, he explains, makes cancer cells more mobile, so they can travel through those leaky vessels to new locations. It also makes cancer cells behave more like stem cells, so they are better able to survive.

Because cancer therapies such as Imatinib, Sunitinib and others are known to decrease pericytes in tumors, the scientists next carried out the same experiments in mice with primary tumors. only this time, they used the chemotherapy drugs Imatinib and Sunitinib instead of genetic programs to decrease pericyte numbers. Both Imatinib and Sunitinib caused 70 percent pericyte depletion -- and they also increased metastasis threefold.

In order to see if their findings are relevant to human patients, the research team examined 130 breast cancer tumor samples of varying cancer stages and tumor sizes and compared pericyte levels with prognoses. The result? The samples with low numbers of pericytes in tumor vasculature correlated with the most deeply invasive cancers, distant metastasis and five to ten year survival rates less than 20 percent.

"These results are quite provocative and will influence clinical programs designed to target tumor angiogenesis," Ronald A. DePinho, president of the University of Texas MD Anderson Cancer Center, said in a press statement. "These impressive studies will inform and refine potential therapeutic approaches for many cancers."

For more information:

http://www.bidmc.org/

Learn more: http://www.naturalnews.com/034693_cancer_drugs_tumors_aggressive.html#ixzz1jxyVw27x

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